GLOMERULAR CAPILLARY VOLUME AND SURFACE AREA DURING ONTOGENY

Capillary Surface Interfaces, Volume 46, Number 7

Volume of the crocodilian brain and endocast during ontogeny

Understanding complex situations and planning difficult actions require a brain of appropriate size. Animal encephalisation provides an indirect information about these abilities. The brain is entirely composed of soft tissue and, as such, rarely fossilises. As a consequence, the brain proportions and morphology of some extinct vertebrates are usually only inferred from their neurocranial endoc...

Increased surface tension decreases pulmonary capillary volume and compliance.

Increased surface tension is an important component of several respiratory diseases, but its effects on pulmonary capillary mechanics are incompletely understood. We measured capillary volume and specific compliance before and after increasing surface tension with nebulized siloxane in excised dog lungs. The change in surface tension was sufficient to increase lung recoil 5 cm H(2)O at 50% tota...

Endothelial cell apoptosis during glomerular capillary lumen formation in vivo.

Transforming growth factor-beta (TGF-beta) stimulates endothelial cell apoptosis in vitro, and inhibition of TGF-beta1 leads to retention of undifferentiated endothelial cells in developing glomerular capillaries and reduced lumen formation in vivo. This study explored the question whether glomerular capillary lumen formation in vivo may involve TGF-beta1-dependent endothelial cell apoptosis. N...

What determines glomerular capillary permeability?

There have been exciting recent advances in our understanding of the structural and molecular biology of the glomerular slit diaphragm, as described in a report in this issue of the JCI. These findings, combined with data on the permeability of the basement membrane and evidence that the endothelium may be a more important barrier than often supposed, are allowing a clearer understanding to eme...